科學家擔憂ADHD藥物有長期副作用
Scientists concerned over long term effects of ADHD medication
Attention-deficit
hyperactivity disorder (ADHD) is a growing problem in children
and teenagers in western countries. The UK's National Institute
for Health and Clinical Excellence (NICE) suggests that it
affects 5% of the school-aged population - the majority being
male. Children with ADHD can experience a range of behavioural
and learning problems but most experience inattention, hyperactivity
and impulsivity, to a greater or lesser degree. Doctors, perhaps
keen for a 'quick fix', often resort to treatment in the form
of prescription stimulant medications such as Ritalin. Based
on an amphetamine-like drug called methylphenidate, it works
by dampening part of the brain called the limbic system, which
causes hyperactivity. Also able to enhance the child's ability
to focus for longer periods of time, Ritalin helps to improve
children's organisational problems, poor self-control and
lack of attention.
There is, however, much controversy surrounding the reported
side effects of such prescription drugs, particularly concerns
over the possible adverse consequences on the sensitive developing
brain. Approved initially for children over six years of age,
more and more prescriptions are being administered for children
as young as two. A study published in the February 2000 issue
of the Journal of the American Medical Association revealed
that the use of stimulants in children between two and four
years old had doubled, and in some cases tripled, between
1991 and 1995 in the US - a phenomenon that is troubling many
child health and development professionals.
Some of the side effects are even more alarming; insomnia,
loss of appetite, vomiting, palpitations, raised blood pressure,
paranoia, psychotic episodes, depression on withdrawal and
even drug dependence are just a few of those reported. Ritalin
has even been linked to the deaths of a small number of children
in the UK and USA, as a result of small vessel damage in the
heart. A recent documentary on Panorama revealed the results
of a major research project carried out by the US-based National
Institutes of Health. The project, called the Multimodal Treatment
Study of Children with ADHD, claims that ADHD drugs such as
Ritalin and Concerta are of no benefit to hyperactive children
and confirmed that these stimulant drugs can even be bad for
their physical development. After studying the effects of
taking Ritalin and other similar ADHD drugs in 600 children
for three years, they found that any short-term benefits had
disappeared, and that taking these drugs long term can result
in stunted growth.
The totality of these findings brings into question the fact
that the NHS is spending £1 million each month on giving Ritalin
to children with ADHD. Figures released under the Freedom
of Information Act reveal that doctors around the UK are writing
around 7,500 prescriptions for Ritalin at a cost of £12.48m
per year. Around 30,000 children in this country are thought
to be taking Ritalin and similar drugs.
With family relationships often being put under a great deal
of stress, it is easy to see why so many children end up on
Ritalin with little objection from their parents. We think
it?s fairly safe to assume that most parents would prefer
a natural, less invasive, solution to their child's behavioural
problems as opposed to one that involves the use of a stimulant
similar in effect to the class A drug, Cocaine. There is,
reassuringly, a rapidly growing body of evidence which suggests
diet plays a significant part in ADHD. Omega-3 fatty acids
(most commonly derived from fish oil) have become relatively
scarce in many modern diets but they are fundamental to healthy
brain development and function. Results from controlled trials
indicate that supplementation with omega-3 - particularly
EPA - can be helpful in the management of ADHD by improving
children's concentration and behaviour.
Omega-3 and omega-6 fatty acids are crucial for maintaining
the correct structure of every cell membrane in the body,
and are crucial for efficient cell messaging in the brain.
Without enough fatty acids, communication between our cells
ceases to operate properly; in the case of the dopamine pathway
(the neurotransmitter implicated in ADHD, and the basis for
which Ritalin has been formulated) this could affect functions
such as attention and concentration - both fundamental factors
in ADHD. By restoring the levels of fatty acids in the brain,
cells are able to communicate properly, and neurotransmitters
resume healthy levels. Of the omega-3 fatty acids, there is
strong evidence to suggest that it is EPA, not DHA, which
is most beneficial for these purposes.
There is substantial supporting evidence which suggests that
deficiencies of certain highly unsaturated fatty acids (particularly)
are associated with childhood ADHD. Several findings indicate
that physical symptoms (including excessive thirst, frequent
urination, rough, dry or scaly skin, dry hair, dandruff, and
soft or brittle nails) behavioural problems (including conduct
disorder, hyperactivity-impulsivity, anxiety, temper tantrums,
and sleep problems) and learning disorders are linked with
low fatty acid levels.
Omega-3 fatty acids are very safe and have many other health
benefits, including improving the cardiovascular system, stabilising
mood and nourishing the joints. There is good evidence to
suggest that omega-3 fatty acids should be seen as complementary
to other methods of management for conditions such as ADHD.
Omega product is a patented and highly concentrated formulation
of ultra-pure EPA (eicosapentaenoic acid) from marine fish
oil and GLA (gamma-linolenic acid) from organic virgin evening
primrose oil, providing a highly concentrated source of omega-3
& omega-6 long-chain fatty acids and botanical triterpenes.
This unique combination of natural fatty acids provides cell
membranes with the nutrients required for efficient chemical
signalling, integral to healthy brain function. Just two capsules
daily provide 560 mg EPA and 200 mg organic EPO, and help
to reverse fatty acid deficiencies by nourishing the brain's
phospholipids. An increasing number of doctors and nutrition
experts are using omega product to treat the symptoms of ADHD and
other behavioural and emotional problems in both children
and adults. |